2025 Proffered Presentations
S070: LONG TERM OUTCOME OF CENTRAL NEUROCYTOMA: A MULTICENTER STUDY OF ELEVN TERTIARY CARE CENTERS
Balgees Ajlan, MD; Dalhousie University
Background: Central neurocytoma is a rare primarily intraventricular tumor that affects young adults. It’s a WHO grade 2 tumor and complete surgical resection is often curative. Due to its peculiar location, gross total resection is often challenging, and adjuvant radiotherapy is sometimes indicated. Factors associated with outcome are not well addressed in the literature.
Methods: A multicenter retrospective cohort study was conducted among 13 tertiary care centers in Saudi Arabia. All eligible patients with a histologically confirmed central neurocytoma between the years of 2000-2022 were included. Modified Rankin Scale (mRS) ≤2 was considered as a favourable outcome while >2 as unfavorable.
Results: A total of 104 patients were included with a mean age of 26± 10.43 years. Majority (85.6%) presented with headache. Pre-operative mRS was 0-2 in 93% of the cases. Mean tumor size was 48 mm (SD 12-91 mm). transcortical approach was used in 62%, transcallosal in 35.2% and trans-sulcal in 2.8%. Gross total resection (GTR) was achieved in 50.7%. Radiotherapy was needed in 40% and Ventriculoperitoneal shunt in 38.6%. The mean duration of follow up was 62 months. favorable outcome was observed in 81.7%. The mRs score improved in 31.7%. regressed in 26% and was unchanged in 42.3%. Factors associated with worse outcome included initial mRs of ≥3, tumor size ≥50 mm, and atypical anaplastic histology. Disease progression was observed in 18 (17.8%). Five-year absolute survival rates 91.55%. The only significant predictor of disease progression was the presence of atypical features or anaplasia (P .007). Extent of surgical resection (P 0.877) wasn’t associated with disease progression. Post operative radiotherapy didn’t alter residual progression in patients with subtotal resection (P .170) nor the recurrence rate in those with gross total resection (.365)
Conclusion: Central Neurocytoma cases have a high survival rate with a favourable mRs score at long-term follow up. The extent of surgical resection didn’t alter disease progression nor did the adjuvant radiotherapy.