2025 Proffered Presentations
S215: MENINGIOMAS CAUSING BONY HYPEROSTOSIS HAVE A MORE SEVERE CLINICAL COURSE
Malcolm F McDonald1; A. Basit Khan, MD1; Andrew Chang, MD1; Collin English1; Eric A Goethe, MD1; Sricharan Gopakumar, MD1; Ali Jalali, MD, PhD1; Ganesh Rao, MD1; Arif Harmanci, PhD2; Akdes Harmanci, PhD1; Tiemo J Klisch, PhD1; Akash J Patel, MD1; 1Baylor College of Medicine; 2UT Health Science Center Houston
Meningiomas are the most common primary tumor of the brain and may elicit hyperostosis of the adjacent bone. Whether hyperostosis is related to reactive changes of the overlying bone or by invasion of the tumor itself is unclear. Here, we characterize the clinical differences of meningiomas with hyperostosis from those without hyperostosis. One-hundred and eighty-one primary, non-syndromic, non-radiation induced meningiomas were included (Fig.1A). Preoperative MRI and CT scans were reviewed by a fellowship trained neuroradiologist to identify presence of hyperostosis (Fig.1B-C) or bone invasion (Fig.1D-E). Clinical, radiographic, and surgical data were gathered for each patient. Sixty-six (36.5%) meningiomas had radiographic evidence of hyperostosis compared to 115 (63.5%) without. Patients with hyperostosis had more severe presentation with increased rates of emergency admissions (p=0.0320) and seizure presentation (p=0.0480) (Table 1). Hyperostotic tumors preferentially manifested in the convexity, parasagittal, olfactory groove, and sphenoid wing locations (p=0.004) (Table 1). Radiographically, tumors with hyperostosis had higher rates of edema (p=0.0280), midline shift (p=0.010), non-homogeneous enhancement (p=0.001), T2 hyperechoic signal (p=0.001), and bone invasion (p<0.001) (Table 2). Patients with hyperostosis had increased estimated blood loss intraoperatively (p=0.006), longer time in the operating room (p=0.045), and higher rates of craniectomy and cranioplasty (p<0.001, p=0.001) (Table 3). In conclusion, meningiomas with hyperostosis is region specific, related to higher intraoperative complications and present with distinct radiographic features.
